My primary research focus is the plasma membrane organization of B cells and understanding how this controls intracellular signaling. We recently discovered that the humoral immune response is dependent on tetraspanin proteins on B cells, and that tetraspanin microdomains act as novel signaling hotspots in the plasma membrane of B cells. The clinical relevance is shown by our discovery that absence of tetraspanin CD37 leads to spontaneous formation of B cell lymphoma, and predicts clinical outcome in lymphoma patients.
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Radboud University Medical Center, Nijmegen, The Netherlands


Zuidscherwoude M, Dunlock VE, van den Bogaart G, van Deventer SJ, van der Schaaf A, van Oostrum J, Goedhart J, In ‘t Hout J, Hämmerling GJ, Tanaka S, Nadler A, Schultz C, Wright MD, Adjobo-Hermans MJW, van Spriel AB. Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci Signal. 2017

De Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, Jabbar KJ, van den Brand M, van der Schaaf A, Elfrink S, van Houdt IS, Gijbels MJ, van de Loo FAJ, Bennink MB, Hebeda KM, Groenen PJTA, van Krieken JH, Figdor CG, van Spriel AB. Tetraspanin CD37 protects against development of B cell lymphoma. J Clin Invest. 2016

Xu-Monette ZY, Li L, Byrd JC, Jabbar KJ, Manyam GC, de Winde CM, van den Brand M, Tzankov A, Visco C, Wang J, Dybkaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Parsons BM, Winter JN, Wang M, Hagemeister FB, Piris MA, van Krieken JH, Medeiros LJ, Li Y, van Spriel AB, Young KH. Assessment of CD37 B-cell antigen and cell-of-origin significantly improves risk prediction in diffuse large B-cell lymphoma. Blood. 2016

A.B. van Spriel et al. The tetraspanin CD37 orchestrates the α4β1 Integrin-akt signaling axis and supports long-lived plasma cell survival. Sci. Signal. 2012 (Highlighted in Nat. Immunol. 2013)

A.B. van Spriel, et al. The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity. PLoS Pathog. 2009


Lotte de Winde: Tetraspanin CD37 in cell migration and lymphomagenesis. From molecular hypothesis to clinical implications. Awarded: 2017

Malou Zuidscherwoude: Function of Tetraspanin CD53 in antigen-presenting cells. Awarded: 2016

Jiabo Di: Eradicating ovarian cancer stem cells in an immunosuppressive tumour microenvironment. Awarded: 2013

Sven Petersen: The role of Tetraspanin CD63 in antigen presentation via MHC class II. Awarded: 2011 (Birmingham University, UK)

Kate Gartlan: The immunological roles of the Tetraspanins CD37 and TSSC6. Awarded: 2008 (University of Melbourne, Australia)

Current PhD projects

Vera Dunlock: Membrane-proximal PKC signaling in B cells.

Suraya Elfrink: Mechanisms underlying CD37-deficiency in diffuse large B cell lymphoma.

Abbey Arp: Tetraspanins proteins and CD20 in B cell lymphoma.

Rens Peeters: Metabolic signaling in B cells.