Gerco den Hartog

My focus is on the production of local mucosal antibodies under homeostatic conditions and mucosal exposure to allergens or infectious agents. I’m interested in the production of IgA and the functionality of mucosal antibodies. Also, how vaccination could result in mucosal antibodies and the role of such antibodies during exposure to the respective pathogens.


Immunology of Infectious Diseases and Vaccination, Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM)


Gerco den Hartog, Thijs LJ Osch, Martijn Vos, Ben Meijer, Huub FJ Savelkoul, RJ Neerven, Sylvia Brugman, BAFF augments IgA2 and IL‐10 production by TLR7/8 stimulated total peripheral blood B cells. European Journal of Immunology 2018

G den Hartog, RJJ Neerven, JD Boot, APH Jansen, HFJ Savelkoul, House dust mite‐specific IgA2 is associated with protection against eczema in allergic patients. Allergy 2016

G Den Hartog, G De Vries-Reilingh, AM Wehrmaker, HFJ Savelkoul, HK Parmentier, A Lammers, Intestinal immune maturation is accompanied by temporal changes in the composition of the microbiota. Beneficial Microbes 2016

Gerco den Hartog, Richard PMA Crooijmans, Henk K Parmentier, Huub FJ Savelkoul, Nicolaas A Bos, Aart Lammers, Ontogeny of the avian intestinal immunoglobulin repertoire: Modification in CDR3 length and conserved VH-pseudogene usage. Molecular Immunology 2013

Aart Lammers, Willemien H Wieland, Leo Kruijt, Arne Jansma, Trudy Straetemans, Arjen Schots, Gerco den Hartog, Henk K Parmentier, Successive immunoglobulin and cytokine expression in the small intestine of juvenile chicken. Developmental & Comparative Immunology 2010