Our overarching goal is to decipher the molecular mechanisms that control immune cell phenotypes in both homeostasis and disease to identify targets for therapeutic intervention. We work towards this goal by employing state-of-the-art genomics technology to study gene regulatory mechanisms in mouse and human immune cells. Special emphasis is placed on the identification and characterization of gene regulatory elements and transcription factors critical for lymphocyte dysfunction in asthma, autoimmunity and cancer. Disease-relevant cell populations are obtained from mouse models that mimic human immune disorders and patient material from the clinic or collaborations with nearby hospitals.
Department of Pulmonary Medicine, Erasmus MC Rotterdam, the Netherlands
Department of Cell Biology, Erasmus MC Rotterdam, the Netherlands
Stadhouders R, Li BWS, de Bruijn MJW, Gomez A, Rao TN, Fehling HJ, van IWFJ, Lim AI, Di Santo JP, Graf T, et al. Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility. J Allergy Clin Immunol. 2018.
Stadhouders R, Vidal E, Serra F, Di Stefano B, Le Dily F, Quilez J, Gomez A, Collombet S, Berenguer C, Cuartero Y, et al. Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming. Nat Genet. 2018.
Lim AI, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, et al. Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation. Cell. 2017.
Stadhouders R, Lubberts E, Hendriks RW. A cellular and molecular view of T helper 17 cell plasticity in autoimmunity. J Autoimmun. 2018.
Brouwer RW, van den Hout MC, van IWF, Soler E, Stadhouders R. Unbiased Interrogation of 3D Genome Topology Using Chromosome Conformation Capture Coupled to High-Throughput Sequencing (4C-Seq). Methods Mol Biol. 2017
Current PhD Projects
Esmee van der Ploeg: Elucidating the role of innate and adaptive lymphocytes in asthma
Anne van Schoonhoven: Deciphering the molecular control of T cell activity
Jelle Folkerts: Developing strategies to inhibit mast cell activity in allergic disease